Mikejamesmansf 2015-12-08 19:30:52
Blood test results showed a fasting insulin level of 2.6, the reference
should be 6.0-27.0. Is this low level of insulin an unhealthy condition?
My fasting blood glucose was 100, cholesterol and other test were okay.
Age 54, not overweight.
Advice and comments appreciated.
Mike collins 2015-12-08 19:30:56
Your insulin levels are meaningless without units.
Oldal4865 2015-12-08 19:30:59
Well, we’re not endocrinologists or even doctors.
However, your HOMA score looks pretty normal (i.e. Not Insulin Resistant)
2.6 x 100/22.5 = 11.6
(if that insulin value was 2.6 micro-International Units/Liter)
Most/Many (?) Type 2 diabetics in the U.S. become Insulin Resistant years
before developing the symptoms of Type 2 Diabetes. Therefore, it’s a good
thing “not to be Insulin Resistant” at your age)
“HOMEOSTASIS MODEL ASSESSMENT (HOMA) AS A CLINICAL INDEX FOR INSULIN
RESISTANCE IN PATIENTS WITH TYPE 2 DIABETES IN COMPARISON TO THE EUGLYCAEMIC
T. Wiesner, M. Bl her, R. Paschke III
Medical Department, University of Leipzig, Germany
Insulin resistance plays an important role in type 2 diabetes. The gold
standard for the in vivo measurement of insulin resistance is the euglycemic
hyperinsulinemic clamp technique. However, this technique is time-consumig,
expensive and not suitable for epidemiologic studies. The Homeostasis model
assessment (HOMA) was developed as a simple and inexpensive alternative to
the more complex clamp technique. . . .(snip)./ . .For our insulin assay
(MEIA, ABBOTT) we calculated a HOMA of >20 as insulin resistant (optimized
by receiver operating characteristics (ROC)). The specificity of the model
is 89.9% and the sensitivity 84.4% for our patients. The mean HOMA value was
80.17 56 for individuals with insulin resistance and 14.82 9.26 for
insulin sensitive probands (p = 0.01), respectively, as determined by the
clamp technique. In conclusion, our data therefore suggest, that the HOMA is
a suitable and simple method to reliably assess the degree of insulin
resistance in epidemiological studies. . .”
However, on the other hand, your fasting blood glucose (FbG) is a bit
high for a non-diabetic, and your fasting insulin is a bit low. That
might be a symptom of approaching Adult-onset Type 1 diabetes. You are
about the right body build, and right age for adult-onset Type 1 so you
might want to keep an eye on your FbG for the next few years.
If you know any diabetics who test their blood sugars at home (i.e.
“smart” diabetics), you might be able to arrange to borrow their kit now
and then. Otherwise, the Wal-Mart Relion meter and blood glucose testing
strips are about the cheapest on the market and, I think, the strips have a
very long shelf life.
If you run across any announcements by folks offering free diabetes blood
tests (look hard in the newspaper in March and Nov when this happens a lot),
then for certain, run down and get one.
Annette 2015-12-08 19:31:06
Hi there Al,
Where can I find out more about the HOMA method? Do you have a good link
where I could read and understand a bit more about it?
Oldal4865 2015-12-08 19:31:14
.. . . .(snip). . .
.. . .(snip). . .
Links? Yes. Good Links? Sorry, no.
Looking for HOMA stuff is frustrating. This is all I have in my file and
two of them are probably dead links.
Also, no author that I have found so far really explains it, they are more
interested in “using it” in a variety of confusing ways.
However, I took a quick look at Google under HOMA insulin
and it seems promising. I missed a lot of those cites the first time I
went after HOMA references.
Note that the QUICKI method is functionally equivalent to the HOMA method.
Both methods just multiply Fasting Insulin times Fasting Blood Glucose to
produce the variable part of the Function.
However, one of the frustrating aspects of this technque is that neither
the HOMA or QUICKI method uses simple, straightforward mathematical
functions. They made both of them more complicated for what I (as an
engineer) see as no good reason at all, e.g. HOMA: why multiply insulin
by glucose then divide by 22.5. . . .(22.5! What’s that, the doc’s
apartment number?), or take the log of the inverse of the product in the
QUICKI model. (Hey, not even engineers think in terms of the Logarithm of
the Inverse Product, pH and pKa notwithstanding)
Also, one can calculate HOMA/QUICKI using micro-International Units/L, or
pico-mols/Liter for the Insulin, and mg/dL or mmol/L for the bG. That
gives you four different possible combinations and four different values for
transition from normal to high Insulin Resistance.
Getting doctors to agree is sorta like herding cats.
Annette 2015-12-08 19:31:25